Aug 27, 2026
Researchers Reveal How Gatekeeper Enzyme UGCG Controls Glycosphingolipid Synthesis
A team led by H. Eric Xu from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, along with collaborators from Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, and Lingang Laboratory, has revealed the molecular basis of human UGCG function by defining how UGCG recognizes its two substrates, catalyzes glucose transfer, and is regulated by clinically used and clinical-stage inhibitors.
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