A research team led by LI Xutong, ZHENG Mingyue and ZHANG Sulin from Shanghai Institute of Materia Medica of the Chinese Academy of Sciences developed an AI platform, KinomeMETA, for kinase multi-target activity screening. This platform significantly expanded the range of predictable kinase and supported customization by leveraging users' proprietary data.

A research team led by Prof. MA Yingxin from the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences developed an ultra-sensitive detection method for SARS-CoV-2 nucleocapsid protein.

To reveal the behavioral pattern underlying the changes in pain perception during aging and to provide a scientific basis for pain management and treatment in older adults, Dr. KONG Yazhuo and his team from the Institute of Psychology compared the similarities and differences in the perception of two different modalities of stimuli, heat and pressure, between young and older adults by collecting sensory debriefings of these stimuli from young adults and older adults.

A research team led by Prof. PAN Wen from the University of Science and Technology of China of the Chinese Academy of Sciences, in collaboration with research teams led by Prof. ZHU Shu and Prof. SONG Xinyang, demonstrated the causal link between microbial factors and dysfunction of intestinal stem cells (ISCs) in colitis. On the basis of this mechanism, they proposed a possible approach to restore ISC function in colitis.

Researchers led by Prof. LI Chuanyou from the Institute of Genetics and Developmental Biology reported their discovery that REGENERATION FACTOR1 (REF1) is the primary local wound signal that instigates plant regenerative responses. This discovery suggests a convenient method for improving the transformation efficiency of difficult-to-transform crops by boosting their regeneration capacity.

A research group led by Prof. FANG Xianyang from the Institute of Biophysics, together with Prof. LI Xing of the Institute of Zoology, has revealed the structure of RhoBAST and its molecular mechanism of binding and activating tetramethylrhodamine-dinitroaniline by integrating X-ray crystallography, small-angle X-ray scattering, molecular dynamics simulations, and other methods.

Researchers from the Xishuangbanna Tropical Botanical Garden found that the overexpression of the gibberellin synthesis gene JcGA20ox1 can delay the flowering time of Jatropha curcas, while overexpression of the gibberellin degradation gene JcGA2ox6 leads to an earlier flowering time.

Genetic components of the ancient populations in the western Tibetan Plateau are closest to ancient populations in the southern Tibetan Plateau, and their major genetic components have been maintained over the past 3,500 years. In addition, these ancient populations in the western Tibetan Plateau had complex and frequent interactions with ancient populations inside and outside the plateau.

A research team led by Dr. WANG Lan from the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences, identified a linkage between aberrant epigenetic chromatin accessibility and reprogrammed endogenous fructose metabolism in the regulation of leukemogenesis.

Prof. WANG Jiangyun's team from the Institute of Biophysics has resolved the structures of succinate-bound SUCR1-G_q and cis-epoxy succinate (ESA) bound SUCR1-G_i complexes using the single-particle cryo-electron microscopy technology.

A research team led by Eric H. Xu and YANG Dehua from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, along with collaborators, using single-particle cryo-electron microscopy, obtained eight high-resolution structures of the human NET homodimer.

Researchers from Dr. ZHONG Jin's group at the Shanghai Institute of Immunity and Infection of the Chinese Academy of Sciences reported a novel biosafety level 2 (BSL-2) Lassa virus (LASV) reverse genetics system.