Scientists Elucidate Substrate Recognition and Proton Coupling Mechanism of VMAT2
A research team led by Prof. ZHAO Yan from the Institute of Biophysics, in collaboration with Prof. JIANG Daohua from the Institute of Physics, has reported the apo structure of human vesicular monoamine transporter 2 (hVMAT2) at low pH, the complex structures of vesicles facing dopamine, norepinephrine, histamine, and the neurotoxin MPP+ binding, and the complex structure of norepinephrine binding in the cytosol-facing state.
May 24, 2024