Chinese Scientists Show How Fentanyl and Morphine Act on μ Opioid Receptor
Research teams led by H. Eric Xu, ZHUANG Youwen, XIE Xin, and WANG Mingwei from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences reported and analyzed the high-resolution cryogenic electron microscopy (cryo-EM) structures of human μOR activated by opioid analgesics such as fentanyl, morphine, and oliceridine, thus revealing for the first time the mechanisms of recognition and activation of μOR induced by fentanyl and morphine.
Nov 14, 2022