A recent research led by Prof. ZHAO Yan from the Institute of Biophysics of the Chinese Academy of Sciences revealed for the first time the three conformations during the transport process of human dopamine transporter (DAT), identified the substrate binding sites and ion binding sites of human DAT, and intuitively explained the coupling relationship between ion binding and substrate transport.

A team of researchers led by Prof. LIU Xingguo from the Guangzhou Institutes of Biomedicine and Health and Prof. ZHANG Qingjiong from Zhongshan Ophthalmic Center, discovered that mesenchymal stem cell (MSC)-mediated mitochondrial transfer can effectively restore mtDNA and improve mitochondrial function in neural progenitor cells derived from patients with LHON.

A research team led by Prof. LI Xinjian from the Institute of Biophysics identified SLC13A3 as an intracellular transporter of itaconate and revealed that SLC13A3-mediated intracellular transport of itaconate can enhance the antimicrobial innate immunity of hepatocytes.

Recently, a collaborative research by Prof. LI Wei from the Institute of Biophysics of the Chinese Academy of Sciences and Prof. CHEN Ping from the Capital Medical University has unveiled for the first time the molecular mechanism by which the histone variant macroH2A regulates the nucleosome maintenance function of FACT through the critical S139 site.

Research groups from the Institute of Biophysics of the Chinese Academy of Sciences, obtained the cryo-electron microscopy structure of chromatin particles formed by the folding of dodecanucleosome mediated by the linker histone H5 at a resolution of 3.6 angstroms (Å).

Researchers from the Suzhou Institute of Biomedical Engineering and Technology recently proposed a novel mass cytometry barcoding strategy based on UIO-66(Hf/Zr) typed metal organic framework (MOF) utilizing its non-specific binding to cells.

In a study published in Ecology, researchers from Xishuangbanna Tropical Botanical Garden (XTBG) of the Chinese Academy of Sciences explored the interspecific and temporal variation of CNDD and its potential associated factors.

Recently, a collaborative study between the Institute of Biophysics of the Chinese Academy of Sciences and the Institute of Medicinal Plants of the Chinese Academy of Medical Sciences reported multiple complex structures and enzymatic characteristics of the glycosyltransferase SgUGT94-289-3.

In a study published in Nature on July 31, Prof. ZHAO Yan's team from the Institute of Biophysics of the Chinese Academy of Sciences, along with collaborators from the University of Copenhagen, Denmark, used single-particle cryo-electron microscopy to resolve the high-resolution structures of human NET and its various complexes. The research revealed the structural features of NET in multiple functional states and the binding modes of different drug molecules.

In a study published in Functional Ecology, researchers from Xishuangbanna Tropical Botanical Garden investigated putative drivers of the growth-mortality trade-off related to functional traits and ecological niches for 14 tree species in a 20-ha tropical forest in southwest China.They found evidence for an interspecific growth-mortality trade-off at the seedling stage.

In a study published in Nature Immunology on August 5, researchers from the Suzhou Institute of Biomedical Engineering and Technology of the Chinese Academy of Sciences, together with collaborators at Shandong University and Tongji University, discovered the critical role of NPM1 in the progression of IBD.

In a study published in Science Advances, a research team led by Prof. ZHANG Xinzheng from the Institute of Biophysics of the Chinese Academy of Sciences introduced a new algorithm signal-to-noise ratio iterative reconstruction method (SIRM), which purely utilized a computational method to eliminate or reduce distortions in cryo-electron microscopy (cryo-EM) three-dimensional reconstructions caused by preferred orientation problem.