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intrinsic DNA;mutation;mutagen sensitivity;genetic variation

Reduced Intrinsic DNA Curvature Leads to Increased Mutation Rate[Sep 19, 2018]

Recently, researchers from QIAN Wenfeng's Lab at the Institute of Genetics and Developmental Biology, together with collaborators from HE Xionglei's Lab at Sun Yat-sen University, and Prof. Lucas B. Carey at Universitat Pompeu Fabra collaborated to tackle this problem. They characterized a high-density mutational landscape of yeast gene URA3 and calculated the correlation between each of the 17 DNA shape properties and the local mutation rate.

nanoparticle;drug delivery system;research

Chinese Scientists Give New Inspirations on the Design of Efficient Drug Delivery Nanoparticles[Sep 18, 2018]

Recently, researchers from the Shanghai Institute of Materia Medica and the National Center for Nanoscience and Technology provided deep insight into the effect of mechanistic properties of nanoparticle-based drug delivery systems on overcoming multiple biological barriers. The findings offer fundamental guidelines for the engineering of physical properties such as shape, and the mechanism of designing nanoparticles for mucosal and tumor delivery.

homoserine lactone;apoptosis;mitochondrial;cancer therapy;ROS

Study May Reveal A New Potential Candidate for Cancer Therapy[Sep 18, 2018]

Chinese scientists from Institute of Technical Biology and Agriculture Engineering investigated how homoserine lactone, or C12 exerts its pro-apoptotic and anti-tumor effects in vivo and further demonstrated that it could be a potential candidate to assist cancer therapy.

sensor;optical organic vapor sensor;molecule;polymer

Researchers Design Highly-sensitive Optical Organic Vapor Sensor[Sep 19, 2018]

Recently, the research group led by Prof. JIANG Lei at Technical Institute of Physics and Chemistry has made a breakthrough in the construction of highly-sensitive optical organic vapor sensor through polymeric swelling induced variation of fluorescent intensity.

serine;aging;ROS

Preventive Effects of Long-term Serine Administration on Aging and Underlying Mechanisms: Study[Sep 19, 2018]

Researchers in the Institute of Subtropical Agriculture conducted a six-month experiment to explore the effects of serine administration on age-related oxidative stress and the signaling pathway involved. Their findings suggest that L-serine has the potential to be used in the prevention of age-related obesity and oxidative stress.

intravenous general anesthesia;locus coeruleus;propofol;etomidate;norepinephrine;zebrafish

Zebrafish Research Highlights Role of Locus Coeruleus in Anesthesia[Sep 19, 2018]

Recently, researchers from the Institute of Neuroscience and Zunyi Medical College, by using a larval zebrafish model, revealed that two commonly used intravenous anesthetic drugs, propofol and etomidate, suppress the excitability of locus coeruleus neurons via synergic mechanisms – thus inhibiting presynaptic excitatory inputs and inducing membrane hyperpolarization of these cells.

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