High-throughput Single-cell Metabolomic Platform Developed for Deciphering Metabolic Heterogeneity of Stem Cells
Prof. ZHOU Bo's group from the Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences, and the collaborators, have built a high-throughput single-cell metabolomics (hi-scMet) platform from scratch combining antibody staining, pre-fixation, flow sorting, automated sample processing, and matrix-assisted laser desorption ionization mass spectrometry, which is capable of detecting more than 100 metabolites from single cells.
Jan 09, 2024