Nov 20, 2025
Chemerin Receptor Structures Disclose New Mechanism of Lipid Metabolism
A team led by WU Beili from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, along with collaborators, determined the structures of GPR1 bound to chemerin and β-arrestin 1 or β-arrestin 2, as well as the structure of GPR1–β-arrestin 1 complex in the absence of chemerin. They elucidated a picture of arrestin-mediated modulation of GPR1, deepening our understanding of non-canonical GPCR signaling.