A research team led by CHENG Xi and WEN Liuqing from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, WANG Dingyan from the Lingang Laboratory, along with the collaborators, introduced a new carbohydrate-binding site predictor DeepGlycanSite.

A research team led by Prof. CAI Huaqing from the Institute of Biophysics has recently used the Dictyostelium model system and a proteomics-based approach to reveal the molecular mechanism of macropinosome formation controlled by Ras signaling.

Recently, a collaborative research team led by Prof. CHEN Chang from the Institute of Biophysics of the Chinese Academy of Sciences (CAS) and Prof. YAO Yonggang from the Kunming Institute of Zoology of CAS, showed that S-nitrosoglutathione reductase (GSNOR) regulates the S-nitrosation of protein kinase C-alpha (PKCα), affecting PKCα kinase activity, and thereby participating in morphine analgesic tolerance.

Researchers led by Prof. WANG Likun from the Institute of Biophysics have developed a novel fluorescence reporting system that allows researchers to visualize the accumulation of unfolded proteins within the ER lumen in living cells in real time.

Researchers from the Wuhan Botanical Garden analyzed the content, composition, distribution, and biosynthesis of B. striata (BSP), obtained candidate enzyme genes involved in BSP biosynthesis, and characterized the cellulose synthase-like family A gene family in the glucomannan polymerization of the cell wall and BSP.

A research team led by Eric H. Xu and ZHAO Lihua from the Shanghai Institute of Materia Medica, employing single-particle cryo-electron microscopy (cryo-EM) techniques, unveiled three-dimensional structures of SSTR5 in complex with the natural neuropeptide agonist cortistatin-17 (CST17) and clinically approved drug octreotide, thus shedding light on molecular mechanisms underlying SSTR5 activation by these ligands.

Researchers from the Wuhan Botanical Garden determined a new Callicarpa species and named it Callicarpa yongshunensis Wen B.Xu, Xiao D.Li & Yan L.Liu.

Researchers led by Prof. XUE Chaoyou from the Tianjin Institute of Industrial Biotechnology of the Chinese Academy of Sciences, and the collaborator, adopted SpRY to identify functional regulatory elements and essential genetic variants for target gene expression at single-base resolution.

Prof. YANG Wulin's group from the Hefei Institutes of Physical Science has identified a new disease marker that can be used to identify reactive mesothelial cells, which can aid in the diagnosis of mesothelioma and the screening of benign and malignant serous effusions.

A research team led by ZHENG Mingyue from Shanghai Institute of Materia Medica of the Chinese Academy of Sciences conducted a comprehensive study to explore the capabilities of various large language models (LLMs) on five key chemical text mining tasks. This work demonstrates the versatility and efficiency of fine-tuning LLMs for extracting chemical information from literature and provides valuable insights into practical applications of LLMs.

Researchers from the Xishuangbanna Tropical Botanical Garden discussed how the alpine plant Rorippa elata adjusted its phenotypic traits to adapt to environmental changes at different altitudes.

Researchers from the Shanghai Institute of Immunity and Infection, the Fudan University, and the Memorial Sloan Kettering Cancer Center, delved into the assembly and functional mechanisms of the Structural Maintenance of Chromosome (SMC) complex. The complexes play a crucial role in the highly ordered and dynamic assembly of eukaryotic genomes into chromatin, which further condenses into chromosomes as carriers of genetic information.