Harnessing surface antigens shared by tumor cells and induced pluripotent stem cells could prevent the development of cancer in mice and elicit anti-tumor immune responses in both animal models and human blood samples, a new study showed.

A research team led by Prof. FENG Wei at the Institute of Biophysics, Chinese Academy of Sciences, has made significant strides in understanding the BORC complex, a key player in lysosome transport and localization. They have revealed, for the first time, the coiled-coil structure of the BORC hetero-octameric complex and identified key regions involved in its binding to ARL8.

A research team led by Prof. CHEN Yan at the University of Science and Technology of China developed a non-invasive radio frequency (RF) based system capable of monitoring heart rate variability (HRV) with clinical-grade accuracy over extended periods, representing a leap forward in cardiovascular health monitoring.

A research team led by ZHANG Jiwen from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences synthesized a nano-grid structured carrier based on a boronated cyclodextrin framework (BCF), and revealed that BCF can capture and protect RGD-modified milk-derived EVs (RGD-mEVs@BCF).

A research team led by ZHANG Jiwen and WU Li from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, along with collaborators, using synchrotron radiation X-ray micro-computed tomography (SR-μCT), revealed “3D channel maze” mechanism to control drug release from multiple unit tablets.

A research group led by Prof. BI Yonghong from the Institute of Hydrobiology of the Chinese Academy of Sciences revealed the regulation mechanism of Gibberellic acid-3 (GA3) in enhancing astaxanthin biosynthesis in heterotrophic C. zofingiensis.

A recent study led by Prof. SUN Yonghua from the Institute of Hydrobiology of the Chinese Academy of Sciences unveiled that the intestinal docosahexaenoic acid-phosphatidic acid-phosphatidylglycerol (DHA-PA-PG) axis promotes digestive organ expansion by mediating the use of maternally deposited yolk lipids.

Researchers from Xishuangbanna Tropical Botanical Garden of the Chinese Academy of Sciences and collaborators studied the effects of micro/nanoplastics on multi-trophic biological interactions and ecosystem functions, especially on plants and aboveground-underground (AG-BG) food webs.

A research group led by Prof. LIANG Zhenchang from the Institute of Botany of the Chinese Academy of Sciences has uncovered two transcription factors, VvERF105 and VvNAC72, that dynamically regulate the expression of a hexose transporter, VvSWEET15. This regulation plays a crucial role in promoting hexose accumulation at different developmental stages in grape berries.

Researchers led by Prof. LIU Qi from the University of Science and Technology of China of the Chinese Academy of Sciences, and collaborators, developed a novel deep generative model, PocketGen. This model, based on graph representation learning and protein language models, efficiently generates protein pocket sequences and spatial structures for binding small molecules.

A research team led by Prof. NIE Guangjun from the National Center for Nanoscience and Technology (NCNST) of the Chinese Academy of Sciences and collaborators have demonstrated a tumor membrane antigens-based nanovaccine derived from liposomal doxorubicin treated tumor tissues, which is efficacious in inducing a potent immunological defense against tumors.

A group of Chinese scientists have recently reported that XYLAN O-ACETYLTRANSFERASE 6 (XOAT6) enhances xylan polymerization and folding by forming a complex with IRREGULAR XYLEM10 (IRX10), thus regulating wall strength and recalcitrance in rice.