Researchers Identify Novel Mechanism of Hepatic Gluconeogenesis via PHD3-mediated Hydroxylation of CRTC2
A team led by Prof. LI Yu from the Shanghai Institute of Nutrition and Health, and the collaborators, identified a novel mechanism for the HIF prolyl hydroxylase domain protein 3 (PHD3)-dependent proline hydroxylation of cAMP responsive element binding protein (CREB)-regulated transcriptional coactivator 2 (CRTC2) in the regulation of hepatic gluconeogenesis.
May 31, 2023