Prof. SUN Yu from SINH performed large scale screening of a natural medicinal agent library for senotherapeutic candidates and validated several agents, which showed their excellent potential to serve as senomorphics. This research provided a proof of concept for Rutin as an emerging natural senomorphic agent, and demonstrates an effective therapeutic modality in mitigating age-related pathologies, including but not limited to various malignancies.

In a study published in Nature on July 31, a team of researchers led by H. Eric XU and ZHAO Lihua from the Shanghai Institute of Materia Medica made a breakthrough discovery in the activation mechanisms of class B GPCR small molecule agonists. As this pocket is highly conserved across class B GPCRs and can activate multiple receptors, its discovery could provide new opportunities for developing selective small molecule agonists targeting this pocket such as diabetes, obesity and osteoporosis.

A research team from the Shenzhen Institute of Advanced Technology has developed an integrative technological workflow for biological engineered living materials by synergistically combining tools from bioinformatics, structural biology, and synthetic biology.

Based on non-invasive, easy-to-manipulate near-infrared laser irradiation, researchers from the Institute of Process Engineering and the University of the Chinese Academy of Sciences have developed a flexible and potent design for "on-demand" whole tumor cell vaccine.

Researchers from the Xishuangbanna Tropical Botanical Garden sought to establish a DNA barcoding standard to enable reliable identification of Caragana species, which will aid in quality control procedures especially for highly fragmented herbal materials.

A team led by Prof. WANG Yanli from the Institute of Biophysics of the Chinese Academy of Sciences reported progress on an anti-CRISPR protein called AcrIIC4 which effectively inhibits type II-C Cas9 by preventing the formation of R-loops.

Researchers from the Shenzhen Institute of Advanced Technology and the University of Chicago have discovered semiconductor nanocluster precipitation within the periplasmic space of Gram-negative bacteria for efficient solar-driven chemical production.

Researchers from the Xishuangbanna Tropical Botanical Garden sought to determine species habitat occupancy and the potential influence of human presence on the spatio-temporal distribution pattern of large mammals in a given area, especially in data-poor regions.

A research team led by Prof. TIAN Lijin from the Institute of Botany found that anaerobic fermentation metabolites suppress both photosynthesis and aerobic respiration.

A research team from the Qingdao Institute of Bioenergy and Bioprocess Technology has investigated the protein loop conformational dynamics in Escherichia coli cells by Nuclear Magnetic Resonance Spectroscopy.

A new process developed by researchers at the Qingdao Institute of Bioenergy and Bioprocess Technology reduces bias in gene amplification, opening up whole new vistas of single-cell research.

A collaborative research team led by Profs. JIANG Yi and WANG Liang from the Institute of Psychology has challenged the Preparedness Theory by suggesting that the unconscious fear conditioning does not necessarily involve emotionally prepared stimuli, but is heavily dependent on the spatial frequency of the stimuli.