Researchers from the Shanghai Institute of Materia Medica visualized the Aβ plaques, nerve tracts and nerve processes, somata, and blood vessels simultaneously in the whole brain of mice with Alzheimer's Disease for the first time, without any specific labelling.

Researchers from the Shanghai Institute of Materia Medica and their collaborators have identified novel functional properties of APOBEC3A in regulating lipid metabolism from the perspective of genomic copy number variations.

Ia recent study, a research team led by LI Tiehai from the Shanghai Institute of Materia Medica has developed an efficient method for synthesis of various complex glycopeptides. They performed the liquid-phase synthesis of complex glycopeptides by integrating hydrophobic tag-supported chemical synthesis of peptide with enzyme-catalyzed sugar chain elongation.

In a study published in Science Advances on May 4, a team of researchers led by Profs. WU Beili and ZHAO Qiang from the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences provide structural and mechanistic insights into NPY signal recognition and transduction by determining the cryo-electron microscopy (cryo-EM) structures of three NPY receptors, Y1R, Y2R, and Y4R, in complex with the NPY peptides and Gi protein.

Initiating an immune response to viral infection begins with the detection of pathogen-associated molecular patterns (PAMPs) by pattern-recognition receptors (PRRs). RIG-I, MDA5, and cGAS are major PRRs that can sense viral nucleic acids. Since their activation is strictly regulated by polyubiquitination and deubiquitination, it is important to understand how RIG-I, MDA5, and cGAS are regulated by ubiquitinase and deubiquitinase.

Using species diversity and phylogenetic metrics such as phylogenetic diversity (PD), standardized effect size of PD, net relatedness index, and evolutionary distinctiveness and global endangerment, researchers from the Xishuangbanna Tropical Botanical Garden (XTBG) identified spatial patterns for 158 threatened tree species in Xishuangbanna.

A research group led by Prof. HAN Danxiang from the Institute of Hydrobiology (IHB) has recently found that secondary metabolites mediated oxidative stress facilitated the infection processes by causing decreased resistance of Haematococcus pluvialis to the fungal parasitism.

Dr. TIAN Ye's group from the Institute of Genetics and Developmental Biology has revealed that the protein disulfide isomerase PDI-6 is critical for the inter-tissue stress signaling communication and lifespan regulation in Caenorhabditis elegans.

Supervised by Prof. ZHONG Caihong and Associate Prof. LI Dawei, Ph.D. student LIU Xiaoying from the Wuhan Botanical Garden of the firstly carried out systematic measurements of fruit ascorbic acid content in 48 kiwifruit species and found that the differences in ascorbic acid between kiwifruit species were mainly due to the extent of ascorbic acid accumulation in the early fruit development.

Drs. HUANG Jia and Raymond Chan from the Institute of Psychology and their collaborators have conducted a study to investigate to what extent effort/reward ratio would be related to reward motivation, and whether the relationship between the effort-reward imbalance (ERI) and reward motivation can be differentially moderated by the schizotypal subtypes.

A research team from Xishuangbanna Tropical Botanical Garden investigated the role of the JcSEP3 gene in floral organ development in the woody plant Jatropha curcas.

A recent study published in Cell Metabolism reported a specific cluster of neurons in the ventromedial hypothalamus (VMH) that express preprodynorphin (Pdyn) and can control homeostatic thermogenesis and social interaction-associated hyperthermia. This research identified Pdyn-expressing neurons in the VMH as a novel nucleus that not only responds to cold temperature in the environment and promotes homeostatic thermogenesis, but also modulates social interaction and associated thermogenesis.