Researchers from the Shenzhen Institute of Advanced Technology has reported a novel integrin-facilitated lysosomal degradation (IFLD) strategy using bifunctional compounds as molecular degraders to degrade extracellular and cell membrane-associated proteins.

A research group led by Prof. ZHU Ping at the Institute of Biophysics of the Chinese Academy of Sciences and the collaborators described the in situ structures of the reovirus transcriptase complex in the intact double-layered virion, and the single-layered uncoated cores in the unloaded state, reloaded state, pre-elongation state, and elongation state, respectively, by cryo-EM and sub-particle reconstruction.

Through an extensive search and review of online databases, reports and books, researchers from the Wuhan Botanical Garden have collected and compiled information on the ethnobotany, phytochemistry and pharmacology of Veronicastrum species, which is important for systematically evaluating its medicinal potential for the development of related drugs and promoting the rational development and application of plant resources of this genus.

researchers led by Profs. CHU Chengcai and GAO Caixia from the Institute of Genetics and Developmental Biology revealed that the SD6/ICE2 molecular module controls rice seed dormancy and has great potential for improving PHS tolerance in rice and wheat.

In a recent study, researchers from the Xishuangbanna Tropical Botanical Garden tried to reveal the role and mechanism of CONSTANS (CO) in jasmonate signaling. They revealed that CO is a negative regulator of jasmonate-imposed root growth inhibition and anthocyanin accumulation. It functions together with JASMONATE ZIM-DOMAIN repressors and basic helix-loop-helix subgroup IIId factors in jasmonate signaling.

A research team at the Wuhan Botanical Garden of the Chinese Academy of Sciences identified and characterized AP2/ ERF family from kiwifruit genome and explained the evolution of AP2/ ERF gene family in two main kiwifruit species. Several key regulators in flower development were predicted as well.

Prof. LI Dezhu's research team from the Kunming Institute of Botany has been engaged in angiosperm phylogenetic and evolutionary genomics for decades. Based on their own expertise and extensive literature survey, the researchers reviewed state of the reconstruction of the flowering plant tree of life, and discussed the major challenges faced by phylogenomic studies.

Researchers from the Wuhan Botanical Garden and University of Northern Colorado set up 25 tansects in the Foping National Reserve to detect Bashania fargesii bamboo invasion pattern.

Prof. GAN Yong's team from Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences, in collaboration with Prof. WEI Gang from Fudan University, reported a multifunctional nanocarrier resembling viral surface for oral insulin therapy.

A study led by Prof. ZHAI Qiwei from the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences has revealed that an increase of Lactobacillus and its metabolites after dieting enhanced intestinal lipid absorption and led to quick fat accumulation and obesity in mice. It also showed that this effect could be prevented by a high-protein diet or specific antibiotics that inhibit the growth of intestinal Lactobacillus.

TR128 capsule, a new drug developed by a research team led by Prof. LIU Qingsong at the Hefei Institutes of Physical Science for the treatment of advanced malignant solid tumors, has been approved by the National Medical Products Administration for clinical trials.

A research team led by Prof. WANG Guangce from the Institute of Oceanology has discovered that the complex of phycobiliproteins, fucoxanthin, and krill oil (PFK) can modulate lipid metabolism and improve obesity.