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organophosphate;neuropathy;TRPA1;sensory neuron

Scientists Provide New Insight into the Treatment of Delayed Neuropathy Caused by Insecticides and Chemicals[Aug 09, 2017]

Organophosphates are the active ingredient of many insecticides, herbicides, and nerve agents such as sarin and are also widely used as solvents, plasticizers, and additives in industry. This study revealed a new biological mechanism underlying the neuropathy, as well as the potential drugs to treat it.

NCM;ternary cathode material;lithium-ion battery

Scientists Enhance the Performance of Cathode Material in Low-temperature in Lithium-ion Batteries[Aug 09, 2017]

Recently, Associate Professor WANG Lei's group at Xinjiang Technical Institute of Physics & Chemistry (XTIPC) of Chinese Academy of Sciences constructed a lithium fast ion conductors modified LiNi1/3Co1/3Mn1/3O2 cathode material, which exhibited enhanced electrochemical performance at low temperatures and high rates.

planthopper;crop disease;rice stripe virus;RSV

Scientists Unlock Planthoppers' Role in Rice Stripe Virus Reproduction[Aug 09, 2017]

Recently, researchers from Institute of Zoology of the Chinese Academy of Sciences have discovered how a severe rice virus reproduces inside the small brown planthopper, a major carrier of the virus, and have published this work in eLIFE.

climate change;data reconstruction;proxy data

Warm Periods in the 20th Century Not Unprecedented during the Last 2000 Years[Aug 08, 2017]

Prof. GE Quansheng and his group from the Institute of Geographic Sciences and Natural Resources Research collected a large number of proxies and reconstructed a 2000-year temperature series in China with a 10-year resolution, enabling them to quantitatively reveal the characteristics of temperature change in China over a common era.

triple negative breast cancer;TNBC;breast cancer;YD277;

A Small Molecule Compound to Inhibit the Triple Negative Breast Cancer[Aug 08, 2017]

Previous studies have shown that transcription factor KLF5 is an effective therapeutic target for TNBC. Professor CHEN Ceshi from Kunming Institute of Zoology of Chinese Academy of Sciences and collaborators from University of Texas Medical Branch, Galveston, Texas and Southern Medical University Affiliated Fengxian Hospital, Shanghai studied a small molecule compound ML264 that can inhibit KLF5 in colorectal cancer.

hepatocyte;hepatic transdifferentiation;chemical cocktail

Chemical Cocktails Promote Hepatic Reprogramming with a Single Transcription Factor[Aug 07, 2017]

Recently, Prof. XIE Xin's group discovered that a chemical cocktail (including six small molecules) can promote the reprogramming of mouse fibroblast into hepatocyte-like cells (iHeps) with only one TF (Foxa1, Foxa2 or Foxa3). These iHeps showed typical epithelial morphology, expressed multiple hepatocyte-specific genes including AFP, Albumin, E-cadherin, Hnf4α, etc., and acquired hepatocyte functions, such as albumin secretion, glycogen storage and drug metabolism.


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