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Scientists Develop A New Nanocomposite to Assist Diagnosis and Therapy of Cancer

Dec 25, 2018     Email"> PrintText Size

A joint team from Institute of Technical Biology and Agriculture Engineering, Hefei Institutes of Physical Science and Shanghai Jiao Tong University developed a new nanocomposite. It could be theranostic agent for effectively diagnosis and combinatorial therapy of cancer.

Scientists around the world have been striving for overcoming cancer, in which tumor-selective catalytic nanomedicine may light the way.

Nanoparticle ensembles which possess collective properties of individual nanoparticles hold great potential as multifunctional drug delivery systems (DDS) and bioimaging contrast agents.

However, the clinical translation of these nanoplatforms is greatly limited by their long-term safety issues, including toxicity, degradation, and metabolism of the nanomaterial in the body.

In the work, according to WU Zhengyan, corresponding author of the paper, a TME-responsive biodegradable MnSiO3@Fe3O4 nanoplatform was constructed for dual-mode MRI-guided combinatorial cancer therapy.

Owing to the weak acidity and high GSH content in the TME, the structure of MnSiO3@Fe3O4 nanoplatform was broken and caused the separation of the Fe3O4 nanoparticles and rapid drug and Mn2+ ion release, which would help reduce the interference between their T1 and T2 contrast abilities, and then facilitate dual-mode MRI contrast enhancement.

Meanwhile the exfoliated Fe3O4 and released Mn2+ can accelerate Fenton reaction and generate abundant of hydroxyl radicals, inducing cancer cell apoptosis.

This TME-responsive MRI contrast enhancement would be beneficial to real-time monitor drug release, improving anticancer effects.

Besides, this nanoplatform also effectively decreased the side effect of drug for the body because of the controlled release of drug and targeting delivery.

This work provides a promising avenue for accurate diagnosis and effective therapy of cancer.

This research was supported by the National Natural Science Foundation of China, the Youth Innovation Promotion Association of Chinese Academy of Sciences, the Science and Technology Major Project of Anhui Province, and. Natural Science Foundation of Anhui Province.

 

A mutifunctional nanoplatform is constructed by decorating Fe3O4 nanoparticles on the surface of MnSiO3, followed by grafting PEG on the surface and loading cisplatin into nanoplatform. This well-engineered nanoplatform with TME-responsive biodegradable ability displays outstanding dual-mode MRI-guided combinatorial catalytic nanotherapeutics (the generation of ·OH) and chemotherapy for cancer treatment. (Image by ZHANG Guilong)

(Editor: ZHANG Nannan)

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