/   Home   /   Newsroom   /   Research News

Researchers Developed Portable Multi-scale Ultrasound System for Non-invasive Ultrasonic Neuro-stimulation

Dec 06, 2017     Email"> PrintText Size

An ultrasound research team led by Prof. ZHENG Hairong in Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences developed a portable ultrasound system specifically for ultrasound neuromodulation applications. 

By transmitting acoustic waveforms into brain tissue, ultrasound is able to non-invasively and remotely stimulate the neurons by activating voltage-gated sodium channels.  

Ultrasound has been demonstrated for the stimulation of retina. The inter-neurons beyond photoreceptors were activated to potentially restore some sense of vision. It could also enhance the performance on sensory discrimination without affecting task attention or response bias. Sonication could trigger transient tactile sensations on the hand area contralateral to the sonicated hemisphere.

Therefore, ultrasound has been demonstrated for different scales of neuro-stimulation from single neuron to human brain, which offers a powerful tool for remotely modulating neural activity with non-invasive feature. 

The ultrasound physical parameters including the operating mode, frequency, pulse repetition frequency, intensity and pulse duration are adjustable in a friendly manner.  

The newly developed ultrasound system supports the synchronization input&output to facilitate other neurophysiological devices such as MEA, or patch clamp, which plays a key role in the study of key technologies such as non-invasive neuro-modulation and sonogenetics. 

The new ultrasound neuro-modulation equipment has already been used for the modulation of small animal and non-human primates. 

The paper entitled “A Portable Ultrasound System for Non-Invasive Ultrasonic Neuro-Stimulation”  was published in IEEE Transactions on Neural Systems and Rehabilitation Engineering. 

Nature reported this work in a review paper entitled "Ultrasound for the Brain". 


Figure 1. (a-b) Micro-scale ultrasound stimulation chip and (c) A portable ultrasound neurostimulation system. (Image by SIAT) 


Figure 2. Large scale (Thousands of channels) ultrasound transducer and system specifically for ultrasound neuromodulation. (Image by SIAT) 


(Editor: LI Yuan)


ZHANG Xiaomin

Shenzhen Institute of Advanced Technology

Phone: 86-755-86585299
E-mail: xm.zhang@siat.ac.cn

Related Articles

cancer;medical imaging;ultrasound;breast cancer;mammogram;breast screening;breast cancer screening

China Enlists AI to Diagnose Breast Cancer

Jul 10, 2017

Doctors in China will soon read patient breast scans with the help of machines. The National Clinical Research Center for Cancer (NCRCC) said Friday that it has signed a deal with the Institute of Computing Technology under the Chinese Academy of Sciences (CAS) to use art...

neuron;brain vascular integrity;miR-132;exosome

Neurons Regulate Brain Vascular Integrity by Secreting Exosomes

Apr 25, 2017

A recent study carried out by Dr. DU Jiulin's research group at the Institute of Neuroscience of Chinese Academy of Sciences reported that neurons transfer miR-132 into brain vascular endothelial cells (ECs) via exosomes to promote brain vascular integrity. This study was...

Contact Us

Copyright © 2002 - Chinese Academy of Sciences