/   Home   /   Newsroom   /   Research News

New Insights about Relation between Glycogen and Sucrose Syntheses in Cyanobacteria

Nov 28, 2017     Email"> PrintText Size

Cyanobacteria, former named blue-green algae, have been attracting increasing research interest for the production of biofuels and biochemicals in recent years due to their capability to convert atmosphere CO2 and light energy to carbohydrates by oxygenic photosynthesis.

Many freshwater or marine species of cyanobacteria naturally synthesize and accumulate sucrose when stressed by salt (NaCl), which provides novel possibilities for obtaining sugar feedstock by engineering of cyanobacteria. 

Because sucrose and glycogen syntheses in cyanobacteria share the common precursor glucose-1-phosphate (see figure), it is generally assumed that these two processes compete for the carbon flux under salt stress.  

However, the metabolic engineering group at Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences, recently provided new insights about the role of glycogen synthesis in sucrose synthesis of cyanobacteria. 

Researchers systematically analyzed the effects of reduced and enhanced glycogen pool on sucrose synthesis in an engineered freshwater cyanobacterium Synechococcus elongatus.  

They observed that the stepwise suppression of glycogen synthesis limited rather than stimulated sucrose production under salt stress. They also showed the combination of glycogen overproduction and sucrose phosphate synthase (SPS) overexpression resulted in increased sucrose production.  

Their results suggested that glycogen could serve as a supportive rather than a competitive carbon pool for the synthesis of sucrose in cyanobacteria (see figure).

This finding is useful to guide the metabolic engineering work to optimize the production of sucrose and possibly other products by cyanobacteria. 

Related findings were recently published in Applied and Environmental Microbiology.  

 

 

Salt-induced sucrose synthesis in an engineered strain of Synechoccous elongatus PCC 7942 (Image by  LUO Quan) 

Attachment:

(Editor: LI Yuan)

Contact

Related Articles

reservior;water level;phytoplankton;water level fluctuations;cyanobacteria;ecosystem

Water Level-based Management Helps Control Cyanobacterial Blooms in Subtropical Reservoirs

Apr 06, 2016

The Aquatic Ecohealth Group at the Institute of Urban Environment of Chinese Academy of Sciences examined effects of WLF on phytoplankton communities with emphasis on cyanobacteria dynamics in four subtropical drinking water reservoirs in southeast China. Compared with te...

Contact Us

Copyright © 2002 - 2017 Chinese Academy of Sciences