/   Home   /   Newsroom   /   Research News

Researchers Identify a miRNA that Promotes Human Treg Cell Stability under Inflammation

Oct 12, 2015     Email"> PrintText Size

FOXP3+ Treg cells play a central role in maintaining the balance between immune tolerance and activation. Treg cells have a great plasticity and are not stable under inflammation and other physiological conditions. For instance, upon IL-6 stimulationTreg cells can lose the expression of FOXP3 and the suppressive function. However, the molecular mechanism of Treg cell instability under IL-6 stimuli remains largely unclear.  

Recently, Dr. LI Dan and KONG Chao supervised by Professor LI Bin at Institut Pasteur of Shanghai (IPS), CAS and Professor SHI Guochao at Ruijin Hospital, Shanghai Jiao Tong University revealed a new molecular pathway by which miR-125a-5p reduces the sensitivity of Treg cells toward IL-6 conversion. 

Researchers observed that the expression of miR-125a-5p is lower in resting Treg cells and could be upregulated in a GATA3 dependent manner after TCR activation. IL-6R and STAT3 are the targets of miR-125a-5p in Treg cells. Overexpression of miR-125a-5p increases the stability of Treg cells under IL-6 stimulation and knockdown of miR-125a-5p decreases its stability. TheGATA3/ miR-125a-5p/IL-6R&STAT3/FOXP3 axis is deregulated in Treg cells from PBMC of asthma patients. This research proposes a novel signal pathway in which miR-125a-5p decreases the sensitivity of Treg cellstoward IL-6-mediatedconversion. 

The study entitled “MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression” was published online in Scientific Reports on October 1 2015. 

This work was supported by grants from National Basic Research Program of China (973 Program), and the National Natural Science Foundation of China.

 

Figure A. The suppressive function of Treg cells under Il-6 stimulation. Figure B. Proposed working model for the mechanism of miR-125a-5pregulatingthe stability of Tregcells. (Image by IPS)

Attachment:

(Editor: CHEN Na)

Related Articles

miRNA;tomato;distant-grafting

Scientists Analyze miRNAs Profiles in Distant-Grafting Between Tomato and Lycium

Nov 03, 2016

Micro RNA (miRNA), a class of small RNA, is short (20-24 nt), endogenous and non-coding. Researchers from Wuhan Botanical Garden of Chinese Academy of Sciences comparatively analyzed the miRNA profiles in distant-grafting between tomato and goji through Illumina high-thro...

microRNA;STTM;short tandem target mimic;miRNA

Small Tandem Target Mimic in Rice Helps Achieve Large-scale Functional Blockage of MicroRNAs

May 04, 2017

The research group led by Prof. ZHU Jiankang at Institute of Plant Physiology and Ecology of Chinese Academy of Sciences produced a large collection of transgenic short tandem target mimic (STTM) lines silencing 35 miRNA families in rice as a resource for functional studi...

Contact Us

Copyright © 2002 - Chinese Academy of Sciences