/   Home   /   Newsroom   /   Research in China

Chinese Scientists Develop Heart-on-a-chip Device to Aid Drug Screening

Apr 12, 2018     Email"> PrintText Size

Chinese scientists have developed a "heart-on-a-chip" device to mimic the beat and contraction of cardiac muscle cells in vitro, which could replace non-human animal models for drug screening.

"Organ-on-a-chip" research mainly involves designing an inch-long silicone device that houses a network of organ cells, which can effectively model human organs and show results for drug tests.

A research team led by Zhao Yuanjin from the state key laboratory of bioelectronics at China's Southeast University has successfully added a structural color hydrogel into a heart-on-a-chip and predicted its clinical values. Their findings were published in the journal Science Robotics in March.

The research was inspired by the biological properties of chameleons. Once the color hydrogel is injected into the chip, it shows color changes according to the contraction of cardiac muscle cells.

When related medication is adopted for some specific heart diseases, the conditions of the cardiac muscle cells can be monitored through the color-changing hydrogel, said Zhao.

"This device focuses on building new platforms for the testing and development of new drugs for safety and efficacy. It will not only replace human and non-human animal models for drug screening, but also meet the medical needs of individual patients in the future," Zhao said. (Xinhua)

Attachment:

(Editor: LIU Jia)

Contact

Phone:
E-mail:

Related Articles

drug screening;high-throuput screening;kinase inhibitor;cancer therapy

China Builds World's Largest Kinase-based Whole-cell Screening Library

Apr 28, 2017

After five years of hard work, China has completed the world’s largest kinase-based whole-cell screening library for high-throughput drug assay. The cell library is located in Hefei, capital of Anhui Province, and includes over 150 cell lines. The lib...

Alzheimer’s disease;amyloid β;inhibitor;drug screening;enantioselectivity

Metallo-Supramolecular Complex Targets Amyloid for AD Treatment with Enantioselectivity

Jan 22, 2018

Dr. QU Xiaogang from Changchun Institute of Applied Chemistry and his collaborators took a new strategy whereby directional ligands AB–CD are used to synthesize optically pure head-to-head-to-tail (HHT) asymmetric constitutions in the absence of head-...

Contact Us

Copyright © 2002 - Chinese Academy of Sciences