Main functions: to assist the CAS leadership in the management, coordination and supervision of work; and to provide administrative services for policy-making, administration and public-related affairs of the CAS headquarters. Also included in its responsibilities: organizing important conferences; providing secretarial services; handling correspondence and administrative information; dealing with complaint letters; maintaining external liaisons, public relations and publicity; managing classified documents, files and archives; and financial management at the CAS headquarters; managing the information-based research and development of the Chinese Academy of Sciences, to be responsible for planning , supervising, coordinating, organizing, implementing information-based work and be responsible for establishing regulations and monitoring duties. Other responsibilities include macro-control of security and safety at the CAS as well as appropriate management of headquarters affiliates.

Divisions: Division of General Affairs, Office of Assistants to the Presidents, Division of Documentation and Archives, Division of Information and Publicity, Office of Security, Division of Financial Affairs, Division of Informationzation Affairs, and Division of Offices Administrations.